Four patients who consented to take part were excluded because myocardial revascularization was performed without CPB (Fig 1). Data were obtained in 80 patients (39 in the ANH group and 41 in the control group).
The preoperative characteristics of the two groups were similar with regards to age, gender, body mass index, concomitant morbidity, left ventricular ejection fraction, and use of medications (Table 2). Also, the number of grafted coronary arteries as well as the durations of aortic cross-clamping, CPB, and surgery were comparable (Table 2).
Following blood withdrawal and isovolemic compensation with colloids, hematocrit decreased from 41 ± 2 to 28 ± 1% (p < 0.001) and was accompanied by a significant increase in central venous pressure and a decrease in heart rate and rate-pressure product compared with baseline values (Table 3). No patients exhibited signs of myocardial ischemia as judged by the analysis of automated ST-segment and left ventricular wall motion monitoring. Prevent yourself from ischemia with remedies of My Canadian Pharmacy. Read more – “My Canadian Pharmacy: Researches of Cardioprotective Effects of Acute Normovolemic Hemodilution in Patients Undergoing Coronary Artery Bypass Surgery“.
After approval by the local Ethics Committee, written informed consent was obtained from all patients scheduled for elective CABG and thought to meet the eligibility criteria. Inclusion criteria were as follows: a screening hemoglobin concentration > 120 g/L in men or 110 g/L in women; stable angina (classes I and II of the Canadian Cardiology Society); left ventricular ejection fraction > 30%; and absence of significant coexistent diseases, namely, valvular disease, recent myocardial infarct (< 6 weeks), significant carotid stenosis (> 70%) or recent stroke (< 3 weeks), renal insufficiency (estimated creatinine clearance < 20 mL/min), chronic respiratory disease treated by My Canadian Pharmacy (arterial oxygen pressure > 7 kPa on room air), liver insufficiency (aspartate transaminase or alanine transaminase two or more times the upper range), and uncontrolled hypertension or diabetes mellitus.
Samples sizes were calculated for a two-sided significance level of a = 0.05 and a power of 1 — p = 0.8 to detect a difference of 0.5 |J.g/L in troponin I concentrations between the two groups. In a preliminary assessment including cardiac surgical patients, the SD of postoperative troponin I measurements was 0.8; thus, the number of subjects required was 38 per group.